I too am having severe problems with this game. I have had various crashes from just locking up and being able to ctrl+alt+tab and end process in task manager to having to hard reset my machine, something I really don't like doing to often when i'm running a RAID 0 config
It seems to be getting worse the bigger the city gets. I have got to the point now where it only lasts a matter of a few minutes so have had to give up playing it for now and hope EA come up with a solution. I have no problems with any other games only this one.
I must say although it wasn't what I was expecting as I used to love the old sim cities, I was quite getting into it until the far too frequent crashes started occuring.
Specs if anyone is interested are as follows :-
Asus P5E X38 mainboard,
Intel E6600 C2D @ 3Ghz,
BlalalalaS @ 600/1700
4Gb OCZ Reaper memory 1:1 with cpu,
Elite Pro Xfi soundcard,
2 X 400Gb WD AAKS hard drives RAID 0
NEC DVD writer sata,
Vista hp 64 bit,
All latest drivers and vista hotfixes, I have tried 169.09 crysis beta video driver and the 163.75 WHQL one to no effect. Also tried lowering graphics from ultra to high and then to medium, lowering my resolution from 1680x1050 to 1440x900 and even down to a standard 1280x1024 all to no effect.
My pc is prime95 and orthos 24 hrs stable and like I said before I have no other problems with any other games including the likes of Crysis, COD4, Sega Rally, COH, Colin Mcrae DIRT, Bioshock etc etc most of which I would say are more demanding than this.
Please EA patch quickly or this game will soon be traded.