Having the same problem but not quite as often. Everything is up to date on my PC, got the patch. I'm running on an Atlon duo core, with 3GB of Ram, and a Radeon X1300 (512MB). So the specs are fine.
It occurs generally when interacting with the game, in the sense that if I leave the town Idle, just racking in the simoleons, it would run forever I suspect. Stupid things, like going into the building gallery, or opening a building/sim card...
I lowered graphics quite alot, the game is a hell of a ressource eater, changed sound settings like recommended by EA, and even made sure nothing was in the background, not even an antivirus. Yet I still get these total freezes every hour or so. Extremely annoying given the fact that nothing will un-freeze it, not Alt+Tab, the Start button, Ctrl+Alt+Del, Alt+F4, Alt+Esc, nothing but turning off my computer the way you're not supposed to: staying pressed on the power button.
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